The Arizona Cardinals should come out on top in their game versus the Seattle Seahawks at 8:15 p.m. ET on Thursday, Sept. 25, according to our computer model. If you're seeking additional projections on the final score, spread, and point total, we've got you covered below.
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Seahawks vs. Cardinals Game Info and TV Channel
- When: Thursday, September 25, 2025 at 8:15 p.m. ET
- Where: State Farm Stadium in Glendale, Arizona
- TV: Amazon Prime Video
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Prime Video (Regional restrictions may apply)
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Seahawks vs. Cardinals Odds and Betting Info
- Spread favorite: Seahawks (-1.5)
- Moneyline: Seahawks (-122), Cardinals (+103)
- Total: 43.5 points
Seahawks vs. Cardinals Prediction
- Pick ATS: Cardinals (+1.5)
- Pick OU: Over (43.5)
Prediction:
Cardinals 24 - Seahawks 21
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Seahawks vs. Cardinals Betting Insights
- The Seahawks have won two games against the spread this season.
- The Cardinals have a record of 2-1-0 against the spread this season.
- Seattle has covered the spread when playing as at least 1.5-point favorites in their only opportunity this season.
- Arizona has been an underdog by 1.5 points or more once this season, and covered the spread.
- So far this season, two Seahawks games have gone over the point total.
- So far this year, one Cardinals game has gone over the point total.
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