Photo: Soobum Im / Getty Images Sport / Getty Images
Based on our computer projections, the San Francisco 49ers will beat the Arizona Cardinals when the two teams play at State Farm Stadium on Sunday, Nov. 16, which starts at 4:05 p.m. ET. For our predictions on the spead, point total, and final score, see the rest of the article below.
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49ers vs. Cardinals Game Info and TV Channel
- When: Sunday, November 16, 2025 at 4:05 p.m. ET
- Where: State Farm Stadium in Glendale, Arizona
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 107.7 The Bone
49ers vs. Cardinals Odds and Betting Info
- Spread favorite: 49ers (-3)
- Moneyline: 49ers (-172), Cardinals (+144)
- Total: 48.5 points
49ers vs. Cardinals Prediction
- Pick ATS: 49ers (-3)
- Pick OU: Under (48.5)
Prediction:
49ers 25 - Cardinals 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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49ers vs. Cardinals Betting Insights
- The 49ers are 5-5-0 ATS this season.
- The Cardinals have covered five times in nine chances against the spread this year.
- San Francisco has covered the spread once when favored by 3 points or more this season (in two opportunities).
- Arizona has an ATS record of 3-1 when playing as at least 3-point underdogs this year.
- In the 49ers' 10 games this season, the combined scoring has gone over the point total six times.
- In 2025, five Cardinals games have hit the over.
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