Jaguars vs. Cardinals Week 12 Predictions, Odds and Stats

San Francisco 49ers v Arizona Cardinals - NFL 2025

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According to our computer projections, the Jacksonville Jaguars will beat the Arizona Cardinals when the two teams come together at State Farm Stadium on Sunday, Nov. 23, which begins at 4:05 p.m. ET. For our projections on the spead, point total, and final score, see the rest of the article below.

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Jaguars vs. Cardinals Game Info and TV Channel

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Jaguars vs. Cardinals Odds and Betting Info

  • Spread favorite: Jaguars (-2.5)
  • Moneyline: Jaguars (-132), Cardinals (+112)
  • Total: 47.5 points

Jaguars vs. Cardinals Prediction

  • Pick ATS: Jaguars (-2.5)
  • Pick OU: Under (47.5)

Prediction:

Jaguars 27 - Cardinals 21

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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    Jaguars vs. Cardinals Betting Insights

    • The Jaguars have won five games against the spread this season, while failing to cover five times.
    • The Cardinals are 5-5-0 ATS this year.
    • Arizona has covered the spread twice this year (2-1 ATS) when playing as at least 2.5-point underdogs.
    • A total of five out of 10 Jaguars games this season have gone over the point total.
    • The Cardinals and their opponent have combined to hit the over six out of 10 times this year.

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